Police in Takeo province burned more than 6,300 marijuana plants on Saturday.
Authorities discovered the illegal marijuana plantation in Kirivong district after villagers tipped off local police.
No arrests were made.
A district police officer, who declined to be named because he was not authorised to speak to the media, said the marijuana plants were found in a remote, mountainous area.
“Anti-drug police found 6,321 marijuana plants in a remote part of Preah Bat Choan Chum commune,” he said. “Police uprooted the plants and burned the site.”
The farm was located on Da Thlat Mountain, more than two kilometres from the nearest village.
“The plants were being grown on top of the mountain, which is state land,” the officer said.
He added that the case remained open because police were seeking to arrest the owners of the marijuana.
Last month, 28,114 fresh marijuana plants were seized and burned by police in Kirivong district, while two Vietnamese nationals were arrested as they attempted to smuggle two kilograms of the drug in from Vietnam.